Frequency of Delayed Gastric Emptying Time and Its Associated Risk Factors in Adult Dyspeptic Patients Attending at Gastroenterology Department BSMMU
DOI:
https://doi.org/10.70818/iarjmsr.2024.v05i06.0153Keywords:
Dyspepsia, Gastric Emptying Scintigraphy, Delayed Gastric Emptying, Risk Factors, DiabetesAbstract
Background: Dyspepsia, a common symptom with a broad differential diagnosis, involves various pathophysiologic mechanisms, including delayed gastric emptying, which causes symptoms such as nausea, vomiting, and bloating. Gastric emptying time is essential for dyspepsia evaluation. Objective: The study aimed to measure gastric emptying time in adult dyspeptic patients using Gastric Emptying Scintigraphy (GES) and identify associated risk factors. Materials and Methods: This cross-sectional study was conducted in the Department of Gastroenterology at BSMMU, Dhaka, from January to December 2022. A total of 35 dyspeptic patients meeting the selection criteria were evaluated through detailed history taking, physical examination, laboratory tests, and upper GI endoscopy. GES was performed to assess gastric emptying. Results: The majority of patients were aged 41-50 years (51.4%), with a mean age of 43.7 ± 8.5 years. Females were predominant, and 51.3% had a high BMI. Delayed gastric emptying was observed in 8 (22.8%) patients. GES revealed that 27 patients (77.2%) had normal gastric emptying (<10% retained meal), while 8 patients (22.8%) exhibited delayed emptying (>10% retained meal). Delayed emptying had 27.5% emptied at 60 minutes, 32.0% at 120 minutes, and 70.0% at 240 minutes. Statistically significant risk factors for delayed emptying included age (>50 years, p=0.017), diabetes mellitus (p=0.007), smoking (p=0.001), and hypothyroidism (p=0.007), but no significant difference was observed for gender and hypertension. Conclusion: Delayed gastric emptying is common in dyspeptic patients, with significant predisposing factors including age, obesity, smoking, diabetes, and hypothyroidism. Early identification and management of these risk factors are crucial for effective treatment.
References
Moshiree, B., Potter, M., & Talley, N. J. (2019). Epidemiology and pathophysiology of gastroparesis. Gastrointestinal Endoscopy Clinics, 29(1), 1-14.
Asano, H., Tomita, T., Nakamura, K., Yamasaki, T., Okugawa, T., Kondo, T., ... & Miwa, H. (2017). Prevalence of gastric motility disorders in patients with functional dyspepsia. Journal of Neurogastroenterology and Motility, 23(3), 392.
Asano, H., Tomita, T., Nakamura, K., Yamasaki, T., Okugawa, T., Kondo, T., ... & Miwa, H. (2017). Prevalence of gastric motility disorders in patients with functional dyspepsia. Journal of Neurogastroenterology and Motility, 23(3), 392.
Goyal, R. K., Guo, Y., & Mashimo, H. (2019). Advances in the physiology of gastric emptying. Neurogastroenterology & Motility, 31(4), e13546.
Deane, A. M., Chapman, M. J., Reintam Blaser, A., McClave, S. A., & Emmanuel, A. (2019). Pathophysiology and treatment of gastrointestinal motility disorders in the acutely ill. Nutrition in Clinical Practice, 34(1), 23-36.
Eusebi, L. H., Ratnakumaran, R., Bazzoli, F., & Ford, A. C. (2018). Prevalence of dyspepsia in individuals with gastroesophageal reflux–type symptoms in the community: a systematic review and meta-analysis. Clinical Gastroenterology and Hepatology, 16(1), 39-48.
Vijayvargiya, P., Jameie-Oskooei, S., Camilleri, M., Chedid, V., Erwin, P. J., & Murad, M. H. (2019). Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis. Gut, 68(5), 804-813.
Miwa, H., Oshima, T., Tomita, T., Fukui, H., Kondo, T., Yamasaki, T., & Watari, J. (2019). Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center. Journal of Gastroenterology, 54, 305-311.
Tack, J., & Camilleri, M. (2018). New developments in the treatment of gastroparesis and functional dyspepsia. Current opinion in pharmacology, 43, 111-117.
Vijayvargiya, P., Jameie-Oskooei, S., Camilleri, M., Chedid, V., Erwin, P. J., & Murad, M. H. (2019). Association between delayed gastric emptying and upper gastrointestinal symptoms: a systematic review and meta-analysis. Gut, 68(5), 804-813.
Zheng, T., & Camilleri, M. (2021). Management of gastroparesis. Gastroenterology & Hepatology, 17(11), 515.
Liu, W., Jin, Y., Wilde, P. J., Hou, Y., Wang, Y., & Han, J. (2021). Mechanisms, physiology, and recent research progress of gastric emptying. Critical reviews in food science and nutrition, 61(16), 2742-2755.
Nassar, Y., & Richter, S. (2018). Gastroparesis in non-diabetics: associated conditions and possible risk factors. Gastroenterology Research, 11(5), 340.
Kouitcheu Mabeku, L. B., Noundjeu Ngamga, M. L., & Leundji, H. (2018). Potential risk factors and prevalence of Helicobacter pylori infection among adult patients with dyspepsia symptoms in Cameroon. BMC infectious diseases, 18, 1-11.
Camilleri, M., Chedid, V., Ford, A. C., Haruma, K., Horowitz, M., Jones, K. L., ... & Stanghellini, V. (2018). Gastroparesis. Nature reviews Disease primers, 4(1), 41.
Ford, A. C., Mahadeva, S., Carbone, M. F., Lacy, B. E., & Talley, N. J. (2020). Functional dyspepsia. The Lancet, 396(10263), 1689-1702.
Van de Putte, P., Vernieuwe, L., Jerjir, A., Verschueren, L., Tacken, M., & Perlas, A. (2017). When fasted is not empty: a retrospective cohort study of gastric content in fasted surgical patients. BJA: British Journal of Anaesthesia, 118(3), 363-371.
Fosso, C. L., & Quigley, E. M. (2018). A critical review of the current clinical landscape of gastroparesis. Gastroenterology & Hepatology, 14(3), 140.
Mayor, V., Aponte, D., Prieto, R., & Orjuela, E. (2020). Current diagnosis and treatment of gastroparesis: A systematic literature review. Revista colombiana de Gastroenterología, 35(4), 471-484.
eA, N. E. W. (2021). American Gastroenterological Association. Gastroenterology, 98(5 Part 2).
Grover, M., Farrugia, G., & Stanghellini, V. (2019). Gastroparesis: a turning point in understanding and treatment. Gut, 68(12), 2238-2250.
Fosso, C. L., & Quigley, E. M. (2018). A critical review of the current clinical landscape of gastroparesis. Gastroenterology & Hepatology, 14(3), 140.
Fox, M. R., Kahrilas, P. J., Roman, S., Gyawali, C. P., Scott, S. M., Rao, S. S., ... & International Working Group for Disorders of Gastrointestinal Motility and Function. (2018). Clinical measurement of gastrointestinal motility and function: who, when and which test?. Nature reviews Gastroenterology & hepatology, 15(9), 568-579.
Nahar, J., Nishat, N., Shoaib, A. S. M., & Hossain, Q. (2024). Market Efficiency And Stability In The Era Of High-Frequency Trading: A Comprehensive Review. International Journal of Business and Economics, 1(3), 1-13.
Hossain, Q., Yasmin, F., Biswas, T. R., & Asha, N. B. (2024). Data-Driven Business Strategies: A Comparative Analysis of Data Science Techniques in Decision-Making. Sch J Econ Bus Manag, 9, 257-263.
Hossain, Q., Hossain, A., Nizum, M. Z., & Naser, S. B. (2024). Influence of artificial intelligence on customer relationship management (crm). International Journal of Communication Networks and Information Security, 16(3), 653-663.
Hossain, Q., Yasmin, F., Biswas, T. R., & Asha, N. B. (2024). Integration of Big Data Analytics in Management Information Systems for Business Intelligence. Saudi J Bus Manag Stud, 9(9), 192-203.
Borna, N. A., Khatun, M. M., Lina, K. S. N., & Khatun, W. (2024). Role of Minimally Invasive Surgery in Managing Ovarian Cysts: A Study of Postoperative Recovery. IAR Journal of Medicine and Surgery Research, 5(5), 32-40.
Seid, A., Tamir, Z., & Demsiss, W. (2018). Uninvestigated dyspepsia and associated factors of patients with gastrointestinal disorders in Dessie Referral Hospital, Northeast Ethiopia. BMC gastroenterology, 18, 1-10.
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Copyright (c) 2024 Md Touhid Al Mahmud, Md Masudur Rahman Khan, Sharmin Quddus, Madhusudan Saha, D M Abu Hena Shahinujjaman (Author)
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