Release Kinetic Study of Matrix Type Transdermal Patch Using an 
Analgesic Drug

doi:N/A

IAR Journal of Medicine and Surgery Research

2020, Volume:1, No 1 : 1-8

Research Article

Release Kinetic Study of Matrix Type Transdermal Patch Using an Analgesic Drug

Mohit Saini

Sneha Singh

Amit Kumar

Lalit Parihar

Mukesh Kumar

⁴

Aroma College Roorkee, Haridwar (UK), India

mt. Manjira Devi Shikshan and Prashikshan Institute Hitanu Dhanari, Uttarkashi, India

R.V.Northland Institute, G.T.road Dadri Greater Noida, Gautam Budh Nagar, (UP), India

⁴

Dr. K. N. Modi Institute of Pharmaceutical Education and Research, Modinagar, (UP), India

Received

July 5, 2020

Revised

July 20, 2020

Accepted

July 29, 2020

Published

Aug. 5, 2020

Abstract

Transdermal therapeutic systems are defined as a self-contained, distinct dosage forms which, when applied to the intact skin, deliver the drug, through the skin at control rate to the systemic circulation. TDDS characterizes one of the most quickly advancing areas of novel drug delivery. TDDS are designed for controlled liberate of drug through the skin into systemic circulation maintaining consistent efficacy and reducing dose of the drug and its related side effects. Present study was conducted to prepare transdermal patch of Tramadol HCL with permeation enhancer to diminish extra side effects and to provide sustain drug delivery. Various kinetics models were examined for optimized formulation. The drug release data of all the formulation were fitted to different kinetic models to find out the kinetics of drug release from transdermal patch. The drug release data was also fitted to zero order (cumulative amount of drug release vs. time) power equation to find out the drug release mechanism.

Keywords

Release Kinetics

TDDS patch & Tramadol HCL.

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DOI: https://doi.org/https://doi.org/10.47310/iarjmsr.v07i01.0191

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