Dyke-Davidoff-Masson Syndrome (DDMS) is a rare neurological disorder marked by cerebral hemiatrophy, presenting with contralateral hemiparesis, seizures, developmental delays, and facial asymmetry. This case report examines an 18-year-old male diagnosed with DDMS, who presented with right-sided weakness, impaired mobility, and speech difficulties that severely impacted his daily activities. Symptoms began at age eight, following an undocumented febrile episode, and progressively worsened, leading to significant functional limitations. MRI findings confirmed cerebral atrophy on the left side with compensatory hypertrophy of the right hemisphere, supporting a DDMS diagnosis. A multidisciplinary rehabilitation approach was implemented, led by a physiatrist and includes neurologist, psychiatrist, physiotherapist, occupational therapist, orthotist, speech therapist, vocational counselor etc. Over six months, the patient’s Functional Independence Measure (FIM) score improved from 82 to 90 (9.8% increase), and his Barthel Index rose from 75 to 80 (6.7% increase). Gross motor, fine motor and speech clarity is also increased. This case highlights the importance of a structured, multidisciplinary approach in managing DDMS, demonstrating that significant functional gains and improved quality of life are achievable despite the challenges of this rare condition.